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Hey Evo crew,
Due to the request of some members on the forum, I have decided to make a follow on from my previous thread where I talked about Semaglutide which can be found here.
I've been using Retatrutide for about three months now after having been on Semaglutide for quite a while, and I wanted to share some thoughts. In my experience, it’s been noticeably easier to lose weight on Retatrutide, even though I’ve been doing less cardio and putting in less effort overall. What really stood out to me is that I’ve had fewer side effects, especially around appetite suppression and digestion. This isn't to say Sema doesn’t work. It does. But Retatrutide just feels like a step up in a lot of ways. Figured it was worth putting together a post for anyone curious or considering making the switch.
From personal experience, it lines up. Hunger is minimal, energy is stable, and I’m dropping weight without needing to rely on cardio the way I used to.
To fully dissolve the peptide, add 3.5ml of bacteriostatic water to the vial. Inject it slowly down the side of the vial to avoid bubbling. You might see some pressure build up inside. If needed, you can use a needle without a plunger inserted to vent the air and avoid leakage.
Let the vial sit for a few minutes and gently swirl (don’t shake) until fully dissolved.
A solid starting point for Retatrutide is around 2mg per week. I prefer daily injections for a smoother and more even effect throughout the week.
Here’s how to break it down:
Inject subcutaneously into the lower stomach (below the belly button is ideal) and rotate sites regularly to prevent irritation.
Probably, yes. Your body may build some tolerance as you go. Like with Semaglutide, listen to how your body feels. If hunger starts creeping back in and weight loss stalls, consider increasing the dose slowly, about 10 percent every 3-4 days and monitor how you respond.
For me, I’ve found a consistent groove with daily dosing and small titrations upward when needed. It’s a bit more hands-on than weekly injections, but you gain more control and flexibility.
If you have any questions or want to share your own experience with Retatrutide, feel free to chime in. Always keen to hear what’s working (or not) for others.
Stay safe and smart.
And a very special thanks to @Eddie Haskell who has helped me immensely throughout my time here.
Due to the request of some members on the forum, I have decided to make a follow on from my previous thread where I talked about Semaglutide which can be found here.
I've been using Retatrutide for about three months now after having been on Semaglutide for quite a while, and I wanted to share some thoughts. In my experience, it’s been noticeably easier to lose weight on Retatrutide, even though I’ve been doing less cardio and putting in less effort overall. What really stood out to me is that I’ve had fewer side effects, especially around appetite suppression and digestion. This isn't to say Sema doesn’t work. It does. But Retatrutide just feels like a step up in a lot of ways. Figured it was worth putting together a post for anyone curious or considering making the switch.
What is Retatrutide?
Retatrutide is a relatively new investigational medication developed by Eli Lilly. It’s being studied for weight management and type 2 diabetes, and what makes it unique is that it acts on three receptors: GLP-1, GIP, and Glucagon.- GLP-1 (Glucagon-Like Peptide-1): Helps reduce appetite, slow gastric emptying, and improve insulin secretion.
- GIP (Gastric Inhibitory Polypeptide): Enhances insulin release and works with GLP-1 for better glucose control.
- Glucagon receptor: Increases energy expenditure and supports fat metabolism.
Clinical Results
In phase 2 trials, people using Retatrutide lost up to 24.2% of their body weight over 48 weeks. That’s more than what was seen in Semaglutide or even Tirzepatide trials. Improvements were also seen in blood sugar, insulin resistance, and overall metabolic markers.From personal experience, it lines up. Hunger is minimal, energy is stable, and I’m dropping weight without needing to rely on cardio the way I used to.
What You Need to Get Started
To begin using Retatrutide, you’ll need four things:- A vial of Retatrutide
- Bacteriostatic water to reconstitute the peptide
- Insulin syringes (1ml with 100 units marked is ideal)
- Alcohol prep pads for sanitizing the injection site
How to Reconstitute Retatrutide
If you’ve purchased a 5mg vial, the total volume including the precipitate is around 4ml. The powder itself takes up about 0.5ml of space.To fully dissolve the peptide, add 3.5ml of bacteriostatic water to the vial. Inject it slowly down the side of the vial to avoid bubbling. You might see some pressure build up inside. If needed, you can use a needle without a plunger inserted to vent the air and avoid leakage.
Let the vial sit for a few minutes and gently swirl (don’t shake) until fully dissolved.
Dosage and Administration
A solid starting point for Retatrutide is around 2mg per week. I prefer daily injections for a smoother and more even effect throughout the week.
Here’s how to break it down:
- 2mg divided by 7 days = ~0.285mg per day
- 1.25mg per ml
- That means 0.125mg per 0.1ml
Inject subcutaneously into the lower stomach (below the belly button is ideal) and rotate sites regularly to prevent irritation.
Expected Benefits
Most people notice:- A sharp reduction in appetite
- Fewer cravings, even for trigger foods
- Faster weight loss with less reliance on exercise
- Improved energy and more stable blood sugar
Side Effects to Watch For
As with any GLP-based compound, there are some side effects that can pop up, especially in the first few weeks. These include:- Nausea or mild GI upset (usually temporary and dose-dependent)
- Constipation or diarrhea
- Slight increase in resting heart rate
- Injection site sensitivity
Will You Need to Increase the Dose Over Time?
Probably, yes. Your body may build some tolerance as you go. Like with Semaglutide, listen to how your body feels. If hunger starts creeping back in and weight loss stalls, consider increasing the dose slowly, about 10 percent every 3-4 days and monitor how you respond.
For me, I’ve found a consistent groove with daily dosing and small titrations upward when needed. It’s a bit more hands-on than weekly injections, but you gain more control and flexibility.
Final Thoughts
Retatrutide is still in clinical trials, but based on current data and personal use, it’s showing serious promise. If you’ve already used Semaglutide or Tirzepatide and are looking for something stronger or more tolerable, it’s definitely worth exploring. Just start low, increase slowly, and see how your body responds.If you have any questions or want to share your own experience with Retatrutide, feel free to chime in. Always keen to hear what’s working (or not) for others.
Stay safe and smart.
Resources and shoutouts
I want to give a special thanks out to my loggers that have helped me greatly, feel free to take a look below and follow along on their journey.- @Pigsy - https://www.evolutionary.org/forums/threads/semaglutide-ozempic-log.102197/
- @Grumpy - https://www.evolutionary.org/forums...de-ozempic-wegovy-vendor-introduction.101669/
- @Allupfromhere - https://www.evolutionary.org/forums...ne-masteron-hgh-retatrutide-cycle-log.104454/
- @Ohdamn - https://www.evolutionary.org/forums...strol-cruise-bridge-cutting-cycle-log.104233/
- @Freki - https://www.evolutionary.org/forums/threads/trt-hgh-retatrutide-proviron-on-a-cruise-log.104036/
- @poopoobum - https://www.evolutionary.org/forums/threads/semaglutide-journey.102943/
And a very special thanks to @Eddie Haskell who has helped me immensely throughout my time here.
, but ill keep my eye on the studies that come out!
