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A Beginner’s Guide to Semaglutide: What You Need to Know About Usage, Benefits, and Side Effects

ZenithHealth

AU Bro
EVO V.I.P.
Hi Evo users, for those that don't know I am an Australian vendor that exclusively sells Semaglutide (Brand name Ozempic, Wegovy etc.), I thought I would write up a quick guide for those that are looking at trying Sema for the first time but are unsure on how exactly to get started.

What is Sema?
Semaglutide has recently gained popularity for its ability to help manage weight and control blood sugar levels. Whether you’re considering it for weight loss or for managing Type 2 diabetes, it’s important to understand how this medication works, how to use it, and what effects you might expect. In this guide, I’ll walk you through everything you need to know

How Does it Work?
Not to get too technical but Semaglutide works by mimicking the effects of GLP-1, which is a hormone that helps lower blood sugar by increasing insulin release and reducing the amount of glucose your liver produces. Additionally, GLP-1 slows down the emptying of your stomach, making you feel fuller for longer and reducing hunger, which can aid in weight loss.

What do I need to get started?
There are 4 items you need to get started:
1: A vial of Sema (My thread)
2: A vial of Bacteriostatic water for diluting the Sema to the desired level (Web link)
3: Syringes; I find that insulin syringes work great (Kogan Link)
4: Alcohol prep pads to clean the site before injection (Amazon link)
All of the 4 items above you can see in image "1" attached


I have all the items what do I do next?
Now that you have all the required items the next thing you need to do is to dilute the substance to the desired volume.
If you purchased one of my 5mg vials, the total volume (including the precipitate) is about 4ml, so the precipitate itself takes up about 0.5ml of volume, I recommend diluting to the maximum 4ml to ensure the precipitate fully dissolves in the solution.

Diluting is as simple as injecting 3.5ml of bacteriostatic water into the vial, be careful though as the pressure inside the vial can build up due to the trapped air inside as you can see in image "2", to release the pressure simply remove the plunger of the insulin syringe completely out of the barrel, and then insert the needle back into the vial, this will allow the pressure to escape as you can see in image "3"

I have now diluted the solution what about dosage?
Assuming you've diluted 5mg of Semaglutide into a total volume of 4ml, each 0.1ml of the solution will contain approximately 0.125mg of Semaglutide. For first-time users, I recommend starting with a daily injection of about 0.05ml (roughly 0.06mg of Semaglutide) to assess how your body reacts. I emphasize daily injections because, if you’re comfortable with pricking yourself every day, they are far superior to weekly injections. Daily injections allow you to better monitor the effects and adjust your dosage as needed. In contrast, with weekly injections, the effect tends to be more intense at the beginning of the week and gradually tapers off, which may increase the likelihood of overeating towards the end of the week.

@Pigsy did an amazing logging in this thread here that talks about the benefits of daily injections over weekly, well worth a read and a follow!

How do I administer it?
Take the insulin syringe and draw out the desired volume, then get an alcohol pad and clean the site, I recommend the fattiest part of your belly, I tend to do below my belly button, this is a great site as there are very few blood vessels there and a lot of subcutaneous fat to inject into, simply insert the syringe and inject away.

Expected benefits?
Most people experience a significant reduction in hunger and cravings, which can lead to weight loss. Depending on your starting weight, diet, and exercise habits, you can expect to lose around 5-10% of your body weight after several months of consistent use, for me it helped me lose about 20kg (92kg - 72kg) in about 5 months, and it has greatly helped me control my portions and not gain weight unless I intend to.

Will I always be using the same dose?
The simple answer is no, you will build a tolerance on Sema depending on how long you use it for, most people will increase their dose after about 3 weeks to a month, with daily injections you can easily tell if the effects are working well or not, if the effects are starting to diminish I recommend increasing the dose by 10% for a week and see how you fair, for me I started off at 0.05ml / day, but after years of use and blasting 40mg of MENT / day I now take 0.17ml / day which is quite a high dose, but after my blast ends I will go back down to about 0.14ml /day. The rule of thumb with dosing is just to listen to your body and see what its telling you, if you are feeling insatiably hungry, its time to up the dose!

Thanks for reading and good luck!
If there is anything that I have left out in this guide please let me know! Definitely looking forward to hearing everyone's thoughts and experiences.
 

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It does come down to personal preference at the end of the day, but the following reasons are why I would always do daily injections over weekly:

1. Easier to monitor response: With daily dosing, it is alot easier to assess how you are responding to semaglutide and adjust the dosage more effectively on a daily basis.
2. Potential for better post-meal control: Since semaglutide helps to slow gastric emptying and reduce post-meal blood sugar spikes, daily injections could potentially offer more immediate relief from high blood sugar spikes after meals.
3. More consistent appetite suppression: Daily injections offer more consistent appetite suppression, leading to more stable weight loss progress., with weekly injections I felt extremely powerful effects for the first few days, then by day 5 or 6 I am just eating like a pig
4. Less discomfort: with weekly injections the initial days would make eating any meal feel uncomfortable, even though I need to eat to get my calories in for the day it just wasn't enjoyable, I felt bloated and sluggish, was not a good feeling and those feelings would go away by day 2 or 3, with daily there is much less of that.

Those are the main reasons, I am sure there are others as well, but again you should do what works best for you, if you dont mind injecting everyday (I already inject MENT everyday so for me its quite easy) I highly recommend doing it that way.
 
Why daily and not weekly (like ozempic)?
You'll have far less, side effects daily doses then 1 big single dose. I'm only on 0.1mg a day now as feeling good and not feeling hungry
 
I actually haven't tried it yet, but I have heard great things, I might need to add it to my next rotation.

What are the most noticeable affects for you as opposed to just straight Sema?
I’ve not tried just sema myself, but did research it quite a bit before making the call to run tirzepatide. It’s brought my blood glucose down quite a bit, and I find I have really steady energy throughout the day, which I’d see as a result of the GIP pathway being effected.
 
I’ve not tried just sema myself, but did research it quite a bit before making the call to run tirzepatide. It’s brought my blood glucose down quite a bit, and I find I have really steady energy throughout the day, which I’d see as a result of the GIP pathway being effected.
I see, yeah both are very effective in that department, I've just been sticking with Sema because its been working so well, if it aint broke dont fix it right?

But yeah next time I restock Sema I might acquire some tirzepatide as well and give it a try
 
You'll have far less, side effects daily doses then 1 big single dose. I'm only on 0.1mg a day now as feeling good and not feeling hungry

100%. I've told a few people to split there dose up

They actually required less total medication doing more frequent dosing

When under doctors once weekly instructions they were feeling nauseous for the first couple days and not eating, then would binge at the end of the week.
 
100%. I've told a few people to split there dose up

They actually required less total medication doing more frequent dosing

When under doctors once weekly instructions they were feeling nauseous for the first couple days and not eating, then would binge at the end of the week.
That is my experience as well, I believe drug manufacturers recommend dosing once p/w as its more palatable for their patients who are not used to doing self administered injections. Injecting everyday can seem quite daunting if you are not used to it.
 
That is my experience as well, I believe drug manufacturers recommend dosing once p/w as its more palatable for their patients who are not used to doing self administered injections. Injecting everyday can seem quite daunting if you are not used to it.

Thats all it is, they design it for maximal drug adherence
 
You'll have far less, side effects daily doses then 1 big single dose. I'm only on 0.1mg a day now as feeling good and not feeling hungry
I had to stop it pigsy after a couple of weeks 😂 as soon as I laid horizontal id just spew into my mouth 😂 bloody rough couple of weeks haha
 
Haha that does not sound pleasant🙈, what dose were on you on?
😂😂 yeah I just wasn't a fan of the side effects.. from memory 0.5mg or something like that (could be wrong but i just started on the generic start dosage)
 
😂😂 yeah I just wasn't a fan of the side effects.. from memory 0.5mg or something like that (could be wrong but i just started on the generic start dosage)
That is a little higher than what I would normally recommend someone to start off with, but not overly so. You must just be very sensitive to it, if you ever feel like giving it another go maybe start off with half that dose 😂
 
That is a little higher than what I would normally recommend someone to start off with, but not overly so. You must just be very sensitive to it, if you ever feel like giving it another go maybe start off with half that dose 😂
Yes definitely.. I know majority of people see great results.
I have been told to give Retra or Tirza a go if the Sema didn't agree with me
 
Thank you for taking the time to put up this write up. It’s also important to be open about the side effects which can be very much for an issue.
Thanks mate, appreciate it!
Yeah you are absolutely right, the main side effect that comes to mind is definitely discomfort, too high a dose after a big meal and it feels like you have a 40kg dumbbell in your stomach, always start small kids!
 
Thanks mate, appreciate it!
Yeah you are absolutely right, the main side effect that comes to mind is definitely discomfort, too high a dose after a big meal and it feels like you have a 40kg dumbbell in your stomach, always start small kids!

Keep me on point through the holiday season
 

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Thanks mate, glad it had the desired effect:) you reckon next time you go on a shred you will use Sema again?
Yes I would. Very helpful when in shred phase
 
I think @poopoobum is trying to change his life, it's a real hard journey for him but full respect.
I agree 100%. Every journey has to begin somewhere, and he's making great progress—it’s still early days, but im definitely rooting for him, and it's fantastic that he agreed to create that log so we can all follow along with him.
 
I agree 100%. Every journey has to begin somewhere, and he's making great progress—it’s still early days, but im definitely rooting for him, and it's fantastic that he agreed to create that log so we can all follow along with him.
I would in your situation start talking more about retatrutide a lot of good feedback on it.
 
Hi all, just letting everyone know I have a new thread with updated prices and a Janoshik report showing the quality of my product, you can find it here
just letting everyone know I now have Retatrutide & Tirzepatide in stock, you can find my new thread with updated prices here I am also looking for members to log these new products
@ZenithHealth good to see you got retatrutide bro but you need to keep promos to the AU sub we got in the future
 
I had the worst side effects on Sema.
Reta has been a game changer - very minimal sides for me personally
I found semaglutide side effects are directly related to diet of the individual.
Having a very tight diet and very clean digestion is important, think probiotics digestive enzymes psyllium husk. @Wheelhouse87
 
I used Semaglutide last year. I had the dosing 500 mcg weekly. It did not do much for me. I did dose up later. No side effects, but also
no appetite control. Still would get raging craving. Maybe better insulin resistance, but hard for me to tell.

I talk to many gym folks. Feels like it works for some and not for others. Tirzepitide seems to work better for most folks I talk to, especially the appetite control. My plan was to use Tirzepitide this year, but the GLP discussion has moved on the Reta. It seems to be very effective on body builder, so I am trying that angle. I am also reading some are stacking tirz with reta. Not sure I would do that.
 
I'm surprised to hear so many people having adverse reactions to Sema, is it possible dosage was just too high? I only got negative symptoms when I upped my dose too quickly and got some temporary nausea.

I am on Reta now as well and it is pretty damn good I have to say.
I never had any issue with Sema. Following your protocol @ZenithHealth
 
I've had issues with Sema, but once I broke the injection protocol down to 2 times per week it got better.

Worst I get is some nausea, very mild and maybe once or twice a week.
Semaglutide is best with ED microdoses IMO.
 
That's your opinion. In my wifes and my experience once a week works best. We've be n on and off it for 12 months now over the last 18 months. It works perfectly once per week and no sides. Don't understand why people can't use it properly. Bodybuilders always think they know more than anyone else. I actually think it's funny.
We aren't saying its not possible to do well on weekly injections, its just your body goes through large swings, the half life of sema isnt extremely long. You will absolutely feel more powerful effects at the start and less powerful towards the end, microdosing removes that and keeps your body at full saturation consistently.
 
That's your opinion. In my wifes and my experience once a week works best. We've be n on and off it for 12 months now over the last 18 months. It works perfectly once per week and no sides. Don't understand why people can't use it properly. Bodybuilders always think they know more than anyone else. I actually think it's funny.
@RoidRage69 Yes you are not wrong. With a sample size of 2 people, it can work once a week.
Yet, from actual wide range user experience and clients, we know micro dosing works the best for least sides for the majority of users. I'm not saying 100%, but majority do much better with micro-dose.
 
We aren't saying its not possible to do well on weekly injections, its just your body goes through large swings, the half life of sema isnt extremely long. You will absolutely feel more powerful effects at the start and less powerful towards the end, microdosing removes that and keeps your body at full saturation consistently.
yes this is fact.
 
@RoidRage69 Yes you are not wrong. With a sample size of 2 people, it can work once a week.
Yet, from actual wide range user experience and clients, we know micro dosing works the best for least sides for the majority of users. I'm not saying 100%, but majority do much better with micro-dose.
i had the same microdosing was easier with semaglutide sides for me
 
Yes I admin 1ml weekly for my missus and it works how it should,daily is outdated I think
weekly dose can work for many, but it has side effects. Daily or EOD injections with microdosing lower sides and increase results. @Seventieschild but for those who don't like injections 1x/week is fine.
 
weekly dose can work for many, but it has side effects. Daily or EOD injections with microdosing lower sides and increase results. @Seventieschild but for those who don't like injections 1x/week is fine.
Yeah it comes down to personal preferences, I personally do daily injections and I'd recommend it to anyone over weekly
 
Yeah it comes down to personal preferences, I personally do daily injections and I'd recommend it to anyone over weekly
I always suggest to all clients EOD or ED pins with GLP-1s.
 
weekly dose can work for many, but it has side effects. Daily or EOD injections with microdosing lower sides and increase results. @Seventieschild but for those who don't like injections 1x/week is fine.
Yeah if it works then go with it,I know many that pin anabolics daily,I've tried that,I know it's optimal but not for me every day pinning.every 3 days works for me.
 
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