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retatrutide

Livewell I started on 2mg a week then moved up to 4mg a week but was struggling to sleep so split the dose twice a week and got some Nebivolol to bring my heart rate back down seemed to help
 
3x500mcg per week dosed Monday/Wednesday/Friday. Works great to suppress appetite and feel it's best to split the doses so there is a constant suppression of appetite without having to have bigger doses than needed. I used this when I'm deep into a cut and starting to struggle with keeping my calories at 1500-1800 per day.
 
@Sydneycitysupplements has some
About to order some for my mini cut
Iv done it twice some say 1mg to start some say 2mg to start

Id go back to 1mg per week cut into 2 jabs Then as needed jump up by 1mg (not 2mg as others say)
I found good Reta kept me away from foods at low does the most I ever did on 9 weeks was 4mg and I started to feel a bit ill
 
@Sydneycitysupplements has some
About to order some for my mini cut
Iv done it twice some say 1mg to start some say 2mg to start

Id go back to 1mg per week cut into 2 jabs Then as needed jump up by 1mg (not 2mg as others say)
I found good Reta kept me away from foods at low does the most I ever did on 9 weeks was 4mg and I started to feel a bit ill
did you get any increase in effects upping it to 4mg? fat loss wise? etc?
 
did you get any increase in effects upping it to 4mg? fat loss wise? etc?
Yes but really you shoudl start low so you dont have to

1mg per week first 2-3 week

Then 2mg week 3(4) - 6

Then 3mg another 3 weeks and so on.

You really dont need to go all out right away.


I just placed an order with @Sydneycitysupplements for 5 a amtes going to jump on with me as well 2 month cut
 
Yes but really you shoudl start low so you dont have to

1mg per week first 2-3 week

Then 2mg week 3(4) - 6

Then 3mg another 3 weeks and so on.

You really dont need to go all out right away.


I just placed an order with @Sydneycitysupplements for 5 a amtes going to jump on with me as well 2 month cut
nah thats waay too high for myself, ive been on 1.5mg / 2mg for months now, been working great for me :) more so my wife uses it and was curious if the higher the dose the more the fat burn, im up to 2mg and staying lean on 4.2k cals, shes on 3mg a week and has been dropping bodyfat consistently, but you hear of crazy doses of people using like 12mg, and that blows my mind haha
 
nah thats waay too high for myself, ive been on 1.5mg / 2mg for months now, been working great for me :) more so my wife uses it and was curious if the higher the dose the more the fat burn, im up to 2mg and staying lean on 4.2k cals, shes on 3mg a week and has been dropping bodyfat consistently, but you hear of crazy doses of people using like 12mg, and that blows my mind haha
12mg is on the trial and many do get to that level but only when they have been on it for a long time

The lower the better for as long as its working is fine.
My dosage I put up is about half of what most people start with so its considered low.

Glad your getting results on even lower.

But if people want a bit more movement fast the lower end probably wont get most of them where it needs ot be at. But everyone reacts differently from it all so 100% they should start as low as they can for a few weeks to see how it goes.
 
12mg is on the trial and many do get to that level but only when they have been on it for a long time

The lower the better for as long as its working is fine.
My dosage I put up is about half of what most people start with so its considered low.

Glad your getting results on even lower.

But if people want a bit more movement fast the lower end probably wont get most of them where it needs ot be at. But everyone reacts differently from it all so 100% they should start as low as they can for a few weeks to see how it goes.
ok interesting so you feel the higher the dose the faster more pronounced the results? my wife was on 2.5mg and recently did a one off dose of 4mg as she was overseas and she noticed a significant improvement
 
fellas just got some

best way to reconstitute with 10mg?

Is it just 2ml of water we reckon? Or what have you guys been doing?

Cheers
Usually 1ml of bac water
Then each notch on an insulin pin is a 1mg dise
But you can put 2ml if you prefer
 
I only have access to 100 unit syringes

so thought 2ml would make it maybe a bit easier to draw a bit more

but just wanna do whatever is best
There is no best as long as you know what you put in and dose properly there is no issue how much bac water you add within reason obviously
 
I only have access to 100 unit syringes

so thought 2ml would make it maybe a bit easier to draw a bit more

but just wanna do whatever is best
Add 2mL BAC. The "10" unit marker (0.1mL) on your insulin needle will be 500mcg. Nice and easy :)

AJ
 
Just a few more lads as reading those threads gave me a bit of contradictory things

1. Does it 100% have to be refrigerated? Or can get by without it being?

2. Do you have to split dose? Heaps of people in threads saying you must. Others replying conflicting things like it's the dumbest thing ever to think you have to split it. I prefer just one dose given the 6/7 day half life, is this alright?

3. Lots of people saying start on 0.5-1mg and work your way up, others are saying go for 2-4mg, any advice here?

Cheers
 
Just a few more lads as reading those threads gave me a bit of contradictory things

1. Does it 100% have to be refrigerated? Or can get by without it being?

2. Do you have to split dose? Heaps of people in threads saying you must. Others replying conflicting things like it's the dumbest thing ever to think you have to split it. I prefer just one dose given the 6/7 day half life, is this alright?

3. Lots of people saying start on 0.5-1mg and work your way up, others are saying go for 2-4mg, any advice here?

Cheers
Refrigerator after reconstituted is best

Split dose is personal choice ive done both ways prefer split dose personally

Again start dose is up to you i started on 2mg can start wherever you like and build up from there
 
Just a few more lads as reading those threads gave me a bit of contradictory things

1. Does it 100% have to be refrigerated? Or can get by without it being?

2. Do you have to split dose? Heaps of people in threads saying you must. Others replying conflicting things like it's the dumbest thing ever to think you have to split it. I prefer just one dose given the 6/7 day half life, is this alright?

3. Lots of people saying start on 0.5-1mg and work your way up, others are saying go for 2-4mg, any advice here?

Cheers
As Grumpy said, it should be refrigerated.
I’ve split my doses to minimise sides,it can cause nausea,high heart rate and sleep issues.
And for what it’s worth, I’m on 3 mg split over 3 days and I need to remind my self to eat, I’ve dropped 12 kg ,it’s a great addition to drop fat.
All the best brother 👌
 
As Grumpy said, it should be refrigerated.
I’ve split my doses to minimise sides,it can cause nausea,high heart rate and sleep issues.
And for what it’s worth, I’m on 3 mg split over 3 days and I need to remind my self to eat, I’ve dropped 12 kg ,it’s a great addition to drop fat.
All the best brother 👌
@gar71 how have you been? long time haven't seen you update. 12kgs drop is amazing, you should update your log and share
https://www.evolutionary.org/forums/threads/my-trt-journey-log.98878/
 
1. Does it 100% have to be refrigerated? Or can get by without it being?
Yes, Retatrutide must be refrigerated after reconstitution. Dont freeze it though.
2. Do you have to split dose? Heaps of people in threads saying you must. Others replying conflicting things like it's the dumbest thing ever to think you have to split it. I prefer just one dose given the 6/7 day half life, is this alright?
Microdosing is a must, but split dosing (2x/day) is not necessary. i suggest ED microdosing with it.

3. Lots of people saying start on 0.5-1mg and work your way up, others are saying go for 2-4mg, any advice here?
Start with 0.5mgs ED small doses to see how you respond.

Just a few more lads as reading those threads gave me a bit of contradictory things

1. Does it 100% have to be refrigerated? Or can get by without it being?

2. Do you have to split dose? Heaps of people in threads saying you must. Others replying conflicting things like it's the dumbest thing ever to think you have to split it. I prefer just one dose given the 6/7 day half life, is this alright?

3. Lots of people saying start on 0.5-1mg and work your way up, others are saying go for 2-4mg, any advice here?

Cheers
@drlifter can you please update your log, it's been a log time
https://www.evolutionary.org/forums/threads/my-tesamorelin-semaglutide-cycle-log.99200/
 
Yes, Retatrutide must be refrigerated after reconstitution. Dont freeze it though.

Microdosing is a must, but split dosing (2x/day) is not necessary. i suggest ED microdosing with it.


Start with 0.5mgs ED small doses to see how you respond.


@drlifter can you please update your log, it's been a log time
https://www.evolutionary.org/forums/threads/my-tesamorelin-semaglutide-cycle-log.99200/
Hey mate, thanks for getting back to me.

I've looked up the literature/science and literally nothing suggests microdosing?

Can you expand here, other than it being beneficial in the sense of side effects?
 
@drlifter You're absolutely right—there's nothing in the official literature suggesting that microdosing Retatrutide (or GLP-1, GIP or Glucagon receptor agonist) is a requirement. That said, the idea of microdosing typically comes from user experience rather than clinical studies. For many, myself included, splitting the dose can help maintain steady levels, which tends to minimise side effects like nausea or gastrointestinal discomfort that can be more pronounced with larger doses.

At the end of the day, you're still taking the same total amount—just spreading it out. This approach is more about managing tolerance and comfort rather than maximising efficacy.
 
@drlifter You're absolutely right—there's nothing in the official literature suggesting that microdosing Retatrutide (or GLP-1, GIP or Glucagon receptor agonist) is a requirement. That said, the idea of microdosing typically comes from user experience rather than clinical studies. For many, myself included, splitting the dose can help maintain steady levels, which tends to minimise side effects like nausea or gastrointestinal discomfort that can be more pronounced with larger doses.

At the end of the day, you're still taking the same total amount—just spreading it out. This approach is more about managing tolerance and comfort rather than maximising efficacy.

Thanks for the reply mate.

I am stuck in two worlds as I really hate injecting, hence the once per week usually works better for me. But do feel the sides already a bit from Reta - so microdosing might be worth trying and copping pinning a bit more.

See how we go next week!
 
Thanks for the reply mate.

I am stuck in two worlds as I really hate injecting, hence the once per week usually works better for me. But do feel the sides already a bit from Reta - so microdosing might be worth trying and copping pinning a bit more.

See how we go next week!
I’ve been there too. Honestly, a 30g insulin pin (slim pin) is all you need.

I found that squeezing the skin helps block any pain, but at this point, I barely notice it. That said, I did SubQ TRT for three months before I could comfortably use a 27g needle for intramuscular injections—so I get it.

If you’re new to SubQ injections, here are a few tips:
  1. Choose the Right Site: The lower belly or thigh is usually best—plenty of fat, easy to reach. Rotate sites to avoid irritation.
  2. Go Slow and Steady: SubQ is all about a slow, gentle injection. It’s not a race—take your time.
  3. Pinch the Skin: Create a small fat fold to keep it SubQ and avoid muscle.
  4. Warm the Oil: If you’re using oil-based medication, run the syringe under warm water for a few seconds—this makes it flow more easily.
  5. Minimal Pressure Post-Injection: Lightly press with a cotton swab or steri wipe for a few seconds—don’t rub. This reduces bruising.

It’s all about finding what works for you.
 
Thanks for the reply mate.

I am stuck in two worlds as I really hate injecting, hence the once per week usually works better for me. But do feel the sides already a bit from Reta - so microdosing might be worth trying and copping pinning a bit more.

See how we go next week!
Get a pen, so much easier, Mrs does her self ghk- cu daily and reta every few days and she hates needles
 
Get a pen, so much easier, Mrs does her self ghk- cu daily and reta every few days and she hates needles

How do I go about getting these?

I've just been using 1ML syringes from local safe needle exchanges (my local pharmacy) for most things.

As an FYI, never really done injectables. Just orals + reta (did tesa for a bit). So I have only ever injected peptides, no steroids quite yet.

Bit of a noob when it comes to this stuff.
 
I’ve been there too. Honestly, a 30g insulin pin (slim pin) is all you need.

I found that squeezing the skin helps block any pain, but at this point, I barely notice it. That said, I did SubQ TRT for three months before I could comfortably use a 27g needle for intramuscular injections—so I get it.

If you’re new to SubQ injections, here are a few tips:
  1. Choose the Right Site: The lower belly or thigh is usually best—plenty of fat, easy to reach. Rotate sites to avoid irritation.
  2. Go Slow and Steady: SubQ is all about a slow, gentle injection. It’s not a race—take your time.
  3. Pinch the Skin: Create a small fat fold to keep it SubQ and avoid muscle.
  4. Warm the Oil: If you’re using oil-based medication, run the syringe under warm water for a few seconds—this makes it flow more easily.
  5. Minimal Pressure Post-Injection: Lightly press with a cotton swab or steri wipe for a few seconds—don’t rub. This reduces bruising.

It’s all about finding what works for you.
Thanks heaps for this mate
 
How do I go about getting these?

I've just been using 1ML syringes from local safe needle exchanges (my local pharmacy) for most things.

As an FYI, never really done injectables. Just orals + reta (did tesa for a bit). So I have only ever injected peptides, no steroids quite yet.

Bit of a noob when it comes to this stuff.
https://www.evolutionary.org/forums...eedback-reviews-gem-stone.102716/post-1736429

They are reusable, normally come quick but last 1 arrived today took 2 weeks. I think delays over long weekends
 
I've done reta. Did a 20mg with 3ml of bac ots lasted around 2 and a half weeks when I did .4ml on a 27g does that seem too quick? Cause I used chat gpt to check the dosage and that 1ml was 6mg of reta when reconstituted with 3ml of bac into 20mg
 
Thanks for the reply mate.

I am stuck in two worlds as I really hate injecting, hence the once per week usually works better for me. But do feel the sides already a bit from Reta - so microdosing might be worth trying and copping pinning a bit more.

See how we go next week!
@drlifter

The only study I found direct was on mice, but it shows you microdosing potential with retatrutide.
Ma et al. (Cell Metabolism 2025): In mice, microdoses outperformed Tirzepatide in lipid metabolism and inflammation markers.

@drlifter You're absolutely right—there's nothing in the official literature suggesting that microdosing Retatrutide (or GLP-1, GIP or Glucagon receptor agonist) is a requirement. That said, the idea of microdosing typically comes from user experience rather than clinical studies. For many, myself included, splitting the dose can help maintain steady levels, which tends to minimise side effects like nausea or gastrointestinal discomfort that can be more pronounced with larger doses.

At the end of the day, you're still taking the same total amount—just spreading it out. This approach is more about managing tolerance and comfort rather than maximising efficacy.
@juddy said it best here. I find microdosing is based on user experience more than literature.

Going to reference our Retatrutide thread
https://www.evolutionary.org/forums/threads/retatrutide-its-the-real-deal.103339/
 
@juddy said it best here. I find microdosing is based on user experience more than literature.

Going to reference our Retatrutide thread
https://www.evolutionary.org/forums/threads/retatrutide-its-the-real-deal.103339/
100% — Pinning can be daunting, honestly it's painless now I have had enough practice, but I'm still not “comfortable” with it. I find more frequent injections of smaller volumes helps with getting past the psychological side of it, it also means you get more practice and can use a smaller gauge needle too.
 
Sorry to raise an old thread but I’m looking for guidance. Does anybody mix/put their reta in the same syringe? I load Reta and hcg together, am I losing any effectiveness by doing this?
technically you can run peptides together if they are mixed in the same solution (bac water) but with certain ones like gh and reta mainly due to value i shoot them seperate, but things like tb500/bpc157 i put together and shoot and never had an issue hope this helps
 
technically you can run peptides together if they are mixed in the same solution (bac water) but with certain ones like gh and reta mainly due to value i shoot them seperate, but things like tb500/bpc157 i put together and shoot and never had an issue hope this helps
Thank you - I’ll try pinning separately for a month and see what happens… given the cost of Reta I should probably respect it a little more
 
Sorry to raise an old thread but I’m looking for guidance. Does anybody mix/put their reta in the same syringe? I load Reta and hcg together, am I losing any effectiveness by doing this?
In theory you can, but I suggest splitting the Retatrutide and HCG in different pins. Especially with reta, you want to make sure there are no issues and you're getting the proper dosing. @Atypical_CA
Let me ask you, why do you want to use HCG with retatrutide? what is your cycle like here?
 
In theory you can, but I suggest splitting the Retatrutide and HCG in different pins. Especially with reta, you want to make sure there are no issues and you're getting the proper dosing. @Atypical_CA
Let me ask you, why do you want to use HCG with retatrutide? what is your cycle like here?
I’m using Test Cyp (moving to E in my next order) 300mg pw as TRT protocol and running HCG alongside. In all honesty, it’s 50% fighting the needle demon and 50% being lazy/efficient putting those two into the one shot…
 
I’m using Test Cyp (moving to E in my next order) 300mg pw as TRT protocol and running HCG alongside. In all honesty, it’s 50% fighting the needle demon and 50% being lazy/efficient putting those two into the one shot…
@Atypical_CA you wouldn't be the first person to not like pinning, even some pro bodybuilders don't like to pin and they do it ED.
It's just something you have to force yourself to do on schedule, fight hard and you can do it. :D EVO family supports you.

I’m using Test Cyp (moving to E in my next order) 300mg pw as TRT protocol
You are doing self-TRT right? 300mgs/week is more like sports TRT level.
 
@Atypical_CA you wouldn't be the first person to not like pinning, even some pro bodybuilders don't like to pin and they do it ED.
It's just something you have to force yourself to do on schedule, fight hard and you can do it. :D EVO family supports you.


You are doing self-TRT right? 300mgs/week is more like sports TRT level.
Yes self-TRT - it’s a little higher but I’m coming off a very low level to start (and seriously believe my mental health is better thanks to the T) so will see how the bloods look in a month’s time.
 
Yes self-TRT - it’s a little higher but I’m coming off a very low level to start (and seriously believe my mental health is better thanks to the T) so will see how the bloods look in a month’s time.
if you hate pinning do you backload insulin pins? smaller needle less pain etc makes life alot easier especially if you hate needles
 
if you hate pinning do you backload insulin pins? smaller needle less pain etc makes life alot easier especially if you hate needles
I’ve got little 27G needles and use two every time (one to draw one to pin). It’s purely psychological. I hate the idea of sticking something in me but being the fittest dad I can for my girls is more important than a little jab.

As for backloading, that’s what I was questioning as mixing in the syringe originally. Considering the only two BAC peptides I’m taking are Reta and HCG I really shouldn’t mix anything with the Reta…. So it’s separate pins now for me
 
Yes self-TRT - it’s a little higher but I’m coming off a very low level to start (and seriously believe my mental health is better thanks to the T) so will see how the bloods look in a month’s time.
How low was your testosterone levels at the start? @Atypical_CA
I’ve got little 27G needles and use two every time (one to draw one to pin). It’s purely psychological. I hate the idea of sticking something in me but being the fittest dad I can for my girls is more important than a little jab.

As for backloading, that’s what I was questioning as mixing in the syringe originally. Considering the only two BAC peptides I’m taking are Reta and HCG I really shouldn’t mix anything with the Reta…. So it’s separate pins now for me
Pinning is not for everyone, but it's something you have to push through and do. With your sports TRT and peptide use, you should start a LOG journal, have you see the other Logs Aussie EVO family members have?
 
How low was your testosterone levels at the start? @Atypical_CA

Pinning is not for everyone, but it's something you have to push through and do. With your sports TRT and peptide use, you should start a LOG journal, have you see the other Logs Aussie EVO family members have?
Hey mate - levels were 130 I’d like them to be at least 300/400 then continue a maintenance dose at 200/250mg per week.

Honestly I’m worried I’d embarrass myself doing a log here (I’ve seen plenty of the others and they’re truely impressive specimens).

My stress levels from myself (I’m a special kinda person 🤪) and work mean my diet discipline is not there. I’ve achieved my first goal and got off my antidepressant and dealing with work stress well enough; diet gets dealt with mostly with the Reta then just better life style and gyming a lot more. Going through a divorce at the moment doesn’t help either (this wasn’t meant to be a counselling session), but this is the start of the rebuild so if I get myself into a good routine I’ll look to log a little changes and what’s working. Blasting’s not in the cards, but I’m early 40’s looking for a better life so a results-focused approach might see me log things in a little while. I’ll give it some thought, the feedback and accountability might help me
 
Hey mate - levels were 130 I’d like them to be at least 300/400 then continue a maintenance dose at 200/250mg per week.

Honestly I’m worried I’d embarrass myself doing a log here (I’ve seen plenty of the others and they’re truely impressive specimens).
@Atypical_CA bro, I thought the same before I started my log. Seeing how I looked compare to others and what others would think came to mind. However, the EVO family is non-judgemental and offers encouragement and advice.

If nothing else, having a log is for you to track your progress, results and accountability.
 
Hey mate - levels were 130 I’d like them to be at least 300/400 then continue a maintenance dose at 200/250mg per week.

Honestly I’m worried I’d embarrass myself doing a log here (I’ve seen plenty of the others and they’re truely impressive specimens).

My stress levels from myself (I’m a special kinda person 🤪) and work mean my diet discipline is not there. I’ve achieved my first goal and got off my antidepressant and dealing with work stress well enough; diet gets dealt with mostly with the Reta then just better life style and gyming a lot more. Going through a divorce at the moment doesn’t help either (this wasn’t meant to be a counselling session), but this is the start of the rebuild so if I get myself into a good routine I’ll look to log a little changes and what’s working. Blasting’s not in the cards, but I’m early 40’s looking for a better life so a results-focused approach might see me log things in a little while. I’ll give it some thought, the feedback and accountability might help me
Brother this is the last place you should feel embarrassed! Evo is all support and no judgement, we all feel the same at the start bro, vulnerable and out in the open but this is where we start our self growth i promise you. August last year i was 110kg at 35%+ bf. Started my log and am now in the best shape i have been my entire life and truly belive im only just getting started now 😁
Having a log keeps us accountable, keeps us current and available for accurate advice. Keeps us driven to show up for our goals each day.
Ask yourself what do you have to lose by starting one? If your not feeling it after a couple of weeks you can pull the pin but im sure you will love the support that comes with it. All the best legend!
 
Im extremely interested in retratrutide to help not with hunger but with rewiring dopamine, I never get sugar cravings or overeat, natural ectomorph.
All my life I never noticed but I was always doing what my brain wanted to do, gaming porn weed etc.
I have quit all that last year but i sometimes relapse on porn..
Anyways im building discipline and getting better each day and I’m starting to love doing productive shit.
And i’m not looking for a cure just bit of help without taking stimulants.
I heard retratrutide is literally a miracle drug, im undiagnosed adhd and have never had interest in dexies or ritalin but i think retra could give me a tiny boost in living a more productive life.
I want to do 0.5 mg per week, any thoughts from you guys who have tried glp1 drugs?
 
Im extremely interested in retratrutide to help not with hunger but with rewiring dopamine, I never get sugar cravings or overeat, natural ectomorph.
All my life I never noticed but I was always doing what my brain wanted to do, gaming porn weed etc.
I have quit all that last year but i sometimes relapse on porn..
Anyways im building discipline and getting better each day and I’m starting to love doing productive shit.
And i’m not looking for a cure just bit of help without taking stimulants.
I heard retratrutide is literally a miracle drug, im undiagnosed adhd and have never had interest in dexies or ritalin but i think retra could give me a tiny boost in living a more productive life.
I want to do 0.5 mg per week, any thoughts from you guys who have tried glp1 drugs?
Recommend mate 👍🏻 it’s definitely helped with cravings for me when stress is there
 
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