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Community Research Retatrutide - it’s the real deal

Threads marked with the 'Community Research' prefix involve ongoing research, high-quality logs, or in-depth community discussions backed by experience, data, or expert input.

awm1981

V.I.P.
EVO Logger
Wanted to give a quick update! I’ve been running gw501516 from PSL (europharma) and Naps (Pharmaqo) along with retatrutide from us peptides from Naps and now retatrutide from umbrella and the stack for a cut cycle is real.

Since November I’ve been taking the standard 20mg/day gw501516 and started the retatrutide at .25mg/week. I’ve since found the sweet spot of 1.5mg/week. Zero sides no nausea just not hungry which is great for me since I’m always hungry! In a little over 3.5 months I’ve dropped 20 pounds (was around 285 now I’m 265) with little to no strength loss.

The retatrutide is not a long term solution I’ll be cutting it out in the next few months once I get to around 250 to then kick off my test/primo/anavar run in May but it’s been a huge help to get me back on track weight wise!
 
Wanted to give a quick update! I’ve been running gw501516 from PSL (europharma) and Naps (Pharmaqo) along with retatrutide from us peptides from Naps and now retatrutide from umbrella and the stack for a cut cycle is real.

Since November I’ve been taking the standard 20mg/day gw501516 and started the retatrutide at .25mg/week. I’ve since found the sweet spot of 1.5mg/week. Zero sides no nausea just not hungry which is great for me since I’m always hungry! In a little over 3.5 months I’ve dropped 20 pounds (was around 285 now I’m 265) with little to no strength loss.

The retatrutide is not a long term solution I’ll be cutting it out in the next few months once I get to around 250 to then kick off my test/primo/anavar run in May but it’s been a huge help to get me back on track weight wise!
Yeah retatrutide is no joke. Way better for fat loss than semaglutide.
 
you won't go wrong with napsgear and umbrella products

how was your cardio and diet during that?

Hey Steve! Hope all is good!

Yea cardio I do 60-90 mins every other day on the stairmill so that’s been consistent and diet is always clean just the retatrutide takes the hunger edge off.

Like I’m just not hungry and that’s at 1.5mg a week. I have no idea how/why people need upwards of 10-12mg+ per week that blows my mind.

Umbrella and naps have both been great!
 
Yeah retatrutide is no joke. Way better for fat loss than semaglutide.

Yea I originally looked at sema but after seeing Reta I decided to go that way and couldn’t be happier!
 
Wanted to give a quick update! I’ve been running gw501516 from PSL (europharma) and Naps (Pharmaqo) along with retatrutide from us peptides from Naps and now retatrutide from umbrella and the stack for a cut cycle is real.

Since November I’ve been taking the standard 20mg/day gw501516 and started the retatrutide at .25mg/week. I’ve since found the sweet spot of 1.5mg/week. Zero sides no nausea just not hungry which is great for me since I’m always hungry! In a little over 3.5 months I’ve dropped 20 pounds (was around 285 now I’m 265) with little to no strength loss.

The retatrutide is not a long term solution I’ll be cutting it out in the next few months once I get to around 250 to then kick off my test/primo/anavar run in May but it’s been a huge help to get me back on track weight wise!
@awm1981 welcome back to the EVO family bro ;) we missed you big man
your log again started good and cut off and you mia lol
https://www.evolutionary.org/forums...and-napsgear-pharmaqo-ultima-cycle-log.99560/
always sad to see you go though :cry: but happy you back :)
you going to start updating your log?
 
this reatrutide sounds like the real deal.

I just worry about the long-term side effects.
The fact that Retatrutide is in the final stages of human testing indicates it's already passed a lot of safety protocols. It's pretty much the same active ingredients as semaglutide (Ozempic) and Tirzepatide but just adding in a new third ingredient which makes it more effective.

My missus used prescription Ozempic last year (she didn't fit the weight criteria but is friends with her GP). This year she's trying Retatrutide and says it's heaps better - no nausea, easier weight loss.

I'm old school and believe in raw-dogging a cut but everything I read points to these GLP-1 products having so many positive impacts other than weight loss - I'm kind of thinking they're going to be one of those once-in-a-generation game changers.

I remember
- going from black and white TVs to colour.
- the introduction of microwave ovens (no more using the oven to reheat a meal)
- VCRs (meant we no longer had to be home at 7:30pm to watch the A-Team)
- mobile phones
- the internet

Things that changed our lives permanently. GLP-1s will be next.
 
The fact that Retatrutide is in the final stages of human testing indicates it's already passed a lot of safety protocols. It's pretty much the same active ingredients as semaglutide (Ozempic) and Tirzepatide but just adding in a new third ingredient which makes it more effective.

My missus used prescription Ozempic last year (she didn't fit the weight criteria but is friends with her GP). This year she's trying Retatrutide and says it's heaps better - no nausea, easier weight loss.

I'm old school and believe in raw-dogging a cut but everything I read points to these GLP-1 products having so many positive impacts other than weight loss - I'm kind of thinking they're going to be one of those once-in-a-generation game changers.

I remember
- going from black and white TVs to colour.
- the introduction of microwave ovens (no more using the oven to reheat a meal)
- VCRs (meant we no longer had to be home at 7:30pm to watch the A-Team)
- mobile phones
- the internet

Things that changed our lives permanently. GLP-1s will be next.
@Snowbogan I found Retatrutide easier with clients as well.

Are you on cycle yourself? tell us more about it please.
 
I haven’t tried ozempic but one of my buddies was using it. I told him I was planning on trying retatrutide so he switched and he’s so much happier.

As snowbogan said it’s the nausea gone which is the big benefit. Even at 2mg/week my buddy felt nauseous around twice a day with semaglutide. With retatrutide no nausea and same for me at 1.5mg/week.

I’m planning on 4-5 months total use then I’ll be off for probably a year just wanted something to help with the cut as at age 44 and a wife, 3 kids, and a job traveling all over the world it’s tough to stay on track like back when I had zero responsibility 😂
 
@Snowbogan I found Retatrutide easier with clients as well.

Are you on cycle yourself? tell us more about it please.
Have been on a cut over summer. I read that the clinical trials of Reta takes patients from 1mg to 2, then 4 and finally 8 mg per week.

I’ve found that 2mg is ideal for me at 90kgs and 11% bf (DEXA). I have no cravings at all but still enough appetite to hit my protein targets- whereas my missus on 1.5g at 60kgs finds she has no appetite and struggles to eat enough protein.
 
Have been on a cut over summer. I read that the clinical trials of Reta takes patients from 1mg to 2, then 4 and finally 8 mg per week.

I’ve found that 2mg is ideal for me at 90kgs and 11% bf (DEXA). I have no cravings at all but still enough appetite to hit my protein targets- whereas my missus on 1.5g at 60kgs finds she has no appetite and struggles to eat enough protein.
Yea at 1.5mg/week for me I have to force myself to eat and I’m usually always hungry.
 
Yeah retatrutide is no joke. Way better for fat loss than semaglutide.
Ive been interested in combining retatrutide with slu pp 332 for contest prep or far loae in general see if i can avoid clen at all costs and come in looking juat as good.
 
Ive been interested in combining retatrutide with slu pp 332 for contest prep or far loae in general see if i can avoid clen at all costs and come in looking juat as good.
I can't tolerate clen - the stimulant effects are just too much. Retatrutide has been a game changer. You can be on the most savage cut but live normally with no hunger pangs, sleep issues etc.
 
I can't tolerate clen - the stimulant effects are just too much. Retatrutide has been a game changer. You can be on the most savage cut but live normally with no hunger pangs, sleep issues etc.
That sounds like a dream come true, clen scares the hell out of me just like tren does, the heart takes a beating the way it is with what we do, if i can exclude a compound known to cause a ton of damage with the heart over time, and all the bad sides that is a win for me if i cam avoid it.
 
Ive been interested in combining retatrutide with slu pp 332 for contest prep or far loae in general see if i can avoid clen at all costs and come in looking juat as good.
Slu-pp-332 supposed to be really good. I haven’t tried it but it’s exercise in a bottle which seems like it would be fantastic for a cut.

Clen is the worst i was grinding my teeth and sweating my balls off on just 60mcg a day. I tried it for a week, never again.
 
Slu-pp-332 supposed to be really good. I haven’t tried it but it’s exercise in a bottle which seems like it would be fantastic for a cut.

Clen is the worst i was grinding my teeth and sweating my balls off on just 60mcg a day. I tried it for a week, never again.
Yeah see not only that the rpaid heart beat id be afraid it would be beating out if rhymed and cause a stroke or heart attack or afib, i want nothing to do with that nasty stuff, that is why i thought a glp1 with slu pp engery up prime fat burning while in a cut, plus ovwr all good sense of well being, 16 weeks with that or with gw added would be awesome.
 
Have been on a cut over summer. I read that the clinical trials of Reta takes patients from 1mg to 2, then 4 and finally 8 mg per week.

I’ve found that 2mg is ideal for me at 90kgs and 11% bf (DEXA). I have no cravings at all but still enough appetite to hit my protein targets- whereas my missus on 1.5g at 60kgs finds she has no appetite and struggles to eat enough protein.
How about protein intake and size? have you worked on muscle retention doing this? @Snowbogan
 
It’s been a challenge eating my protein targets with no appetite. This is my first real cut on reta so it’s a work in progress. Seem to be retaining strength and size.
@Snowbogan can you please share your LOG journal on this retatrutide? we can help you develop your nutrition and training to match and really guide you as a big EVO family :D
It will take 15 min and EVO family is no judgement zone, we just here to help you.

HOW TO?
  • To really guide you we need more info from you.
  • Please share your diet, training, cardio, sleep, supplements etc log with us in a NEW thread, full log journal so our guidance is based on facts you provide.
  • It will take 15-20 minutes max.
  • We have 100s of years of experience between us, so you need to post a LOG Journal with your stats (weight,height,age, years training, cycle history) diet, training, cardio, supplement, sleep details. If you don't log what you eat or train now, open NOTES on phone and start recording it there and paste here. Very easy.
Please post a Log Journal asap for us

Please click the anabolic forum
https://www.evolutionary.org/forums/forums/anabolic-steroids-and-peds.2/
top RIGHT, you see: +POST THREAD
click that

in Title: write your cycle name, like> My _____ Cycle Log
___ = the name of your log
example: My Retatrutide Cutting cycle Log
in body: write your planned cycle or cycle you doing now, your diet, training and we will help you along on your cycle


here are examples of LOG Journals

https://www.evolutionary.org/forums/threads/s-gentz-recomp-cut-log-2023-2024.96694/
https://www.evolutionary.org/forums/threads/mobsters-training-diary.84438/
https://www.evolutionary.org/forums/threads/roidrage69-log.90127
https://www.evolutionary.org/forums/threads/domestic-supply-bulking-log-25homes-max.97609/
https://www.evolutionary.org/forums...obolan-equipoise-tbol-contest-prep-log.97138/
https://www.evolutionary.org/forums...osterone-deca-primobolan-hgh-cycle-log.97978/
https://www.evolutionary.org/forums...igas-hgh-and-bpc157-recovery-cycle-log.97594/
https://www.evolutionary.org/forums...enbolone-cycle-log-let-the-gains-begin.98399/
https://www.evolutionary.org/forums/threads/pigsy-new-sponsor-ugl-contest-prep-log.96779/
https://www.evolutionary.org/forums/threads/my-2023-2024-log.95956/
https://www.evolutionary.org/forums...stosterone-cardarine-cutting-cycle-log.97281/
https://www.evolutionary.org/forums/threads/roidragewife-female-training-log.95769/
https://www.evolutionary.org/forums/threads/2024-lean-bulking-cycle-log.97986/
https://www.evolutionary.org/forums/threads/my-trt-with-deca-durabolin-log.97962/
https://www.evolutionary.org/forums...bodybuilding-log-masters-55-competitor.97210/
https://www.evolutionary.org/forums/threads/losiol-primobolan-testosterone-log.96581/
https://www.evolutionary.org/forums/threads/roughy-steroid-cycle-and-training.97944/
https://www.evolutionary.org/forums/threads/fatboy999-2024-cycle-log.97936/
https://www.evolutionary.org/forums/threads/testosterone-equipoise-trenbolone-cycle-log.96963/
https://www.evolutionary.org/forums/threads/my-trt-log.98284/
https://www.evolutionary.org/forums/threads/16-week-testosterone-cardarine-n2guard-cycle-log.98034/
https://www.evolutionary.org/forums/threads/training-log-female.90425
https://www.evolutionary.org/forums...tosterone-masteron-primobolan-blast-log.98328
https://www.evolutionary.org/forums/threads/25homes-revenge-transformation-log-2023.88570/
https://www.evolutionary.org/forums...n-season-sponsored-by-nordic-fusion-log.89817
https://www.evolutionary.org/forums/threads/s-gentz-contest-prep-log.87619/
 
Yeah see not only that the rpaid heart beat id be afraid it would be beating out if rhymed and cause a stroke or heart attack or afib, i want nothing to do with that nasty stuff, that is why i thought a glp1 with slu pp engery up prime fat burning while in a cut, plus ovwr all good sense of well being, 16 weeks with that or with gw added would be awesome.
Yea I have a slightly abnormal heartbeat it gets out of rhythm from time to time then pops right back. I’ve had incident monitors, ultrasound of heart, etc everything all good but it’s annoying when it does go out of rhythm which is why stuff like clen is off the table.
 
Yea I have a slightly abnormal heartbeat it gets out of rhythm from time to time then pops right back. I’ve had incident monitors, ultrasound of heart, etc everything all good but it’s annoying when it does go out of rhythm which is why stuff like clen is off the table.
Clenbuterol is not good for the heart, but so are many stims to be fair.
 
Clenbuterol is not good for the heart, but so are many stims to be fair.
Yea I try to manage my caffeine but it’s tough. I 100% stopped all preworkout though I just do coffee and some diet soda.
 
Yea I have a slightly abnormal heartbeat it gets out of rhythm from time to time then pops right back. I’ve had incident monitors, ultrasound of heart, etc everything all good but it’s annoying when it does go out of rhythm which is why stuff like clen is off the table.
Yeah man that is a super smart move, protecting the heart is always my number one priority
 
i have some concerns using these types of anti diabetes drugs for weight loss

1. when you stop using them boomerang effect is likely
2. the way they work by mimicking certain pathways including secreting insulin to blunt appetite isn't a good thing and i can argue counter productive
3. the long term effects it can have on the gut, pancreas, and thyroid

are they better then clen? when it comes to the heart yes although they still can cause a rise in heart rate. clen is a shitty drug and i've never seen more then 5-10% be happy with it. but they do have their own risks as well. seems like overall the iron clad benefit is the way they satiate you where you don't feel hungry and the mere sit of food makes you sick. if thats the case then just will power and discipline would seem to be a natural and healthier way to fix that issue, and not keeping junk in your house

i wouldn't run these compounds for a long period.
 
i have some concerns using these types of anti diabetes drugs for weight loss

1. when you stop using them boomerang effect is likely
2. the way they work by mimicking certain pathways including secreting insulin to blunt appetite isn't a good thing and i can argue counter productive
3. the long term effects it can have on the gut, pancreas, and thyroid

are they better then clen? when it comes to the heart yes although they still can cause a rise in heart rate. clen is a shitty drug and i've never seen more then 5-10% be happy with it. but they do have their own risks as well. seems like overall the iron clad benefit is the way they satiate you where you don't feel hungry and the mere sit of food makes you sick. if thats the case then just will power and discipline would seem to be a natural and healthier way to fix that issue, and not keeping junk in your house

i wouldn't run these compounds for a long period.

If u have time look into slu pp 332 it can change the way people prep for shows, its still fairly new, it is a fascinating compound, maybe podcast episode one day ? 😁
 
If u have time look into slu pp 332 it can change the way people prep for shows, its still fairly new, it is a fascinating compound, maybe podcast episode one day ? 😁
from what i have seen with it. seems very close to sr9009
 
from what i have seen with it. seems very close to sr9009
This is what intrigued me about it.

agonist for the estrogen-related receptor (ERR

Other than the fact it boosts cognitive function and energy production along with a mlte positive wellbeing along with increased metabolism and fat loss.

I never got the energy boost from sr9009, i thought when i got into my cut, combine gw with slu pp 332 and run a log and see if i geg good results with it, for competing if i cam use those instead if clen and other harsh methods, id feel more comfortable. I have a sense of dred thinking about diuretics and clen.
 
This is what intrigued me about it.

agonist for the estrogen-related receptor (ERR

Other than the fact it boosts cognitive function and energy production along with a mlte positive wellbeing along with increased metabolism and fat loss.

I never got the energy boost from sr9009, i thought when i got into my cut, combine gw with slu pp 332 and run a log and see if i geg good results with it, for competing if i cam use those instead if clen and other harsh methods, id feel more comfortable. I have a sense of dred thinking about diuretics and clen.
I really like GW, i'm still using the ones i got in my log.
but i don't use it consistently. i will use it off and on and run it ahead of a workout, so more for endurance and not fat loss.
 
I really like GW, i'm still using the ones i got in my log.
but i don't use it consistently. i will use it off and on and run it ahead of a workout, so more for endurance and not fat loss.
Yeah i tend to cycle it once or twice a year max, mostly when im cutting for that extra boost.
 
whats the highest you guys have run reta? im currently doing 1.5mg a week now on growth phase for health benefits, bloods and insulin sensitivity keeping me lean while growing, when i was dieting down i used 1mg a week reta ad like 300mcg a week sema for the appetite and worked real nice, the mrs is on 2.5mg reta a week and working nicely
 
Honestly the more I see people talking about how great Reta is, the more I see the prices from my suppliers go up.

I'm going to have to start spreading some FUD about how it made my dick fall off or something :ROFLMAO:

FYI, Reta + Tren = Bonkers physique.
 
whats the highest you guys have run reta? im currently doing 1.5mg a week now on growth phase for health benefits, bloods and insulin sensitivity keeping me lean while growing, when i was dieting down i used 1mg a week reta ad like 300mcg a week sema for the appetite and worked real nice, the mrs is on 2.5mg reta a week and working nicely
I stopped at 1.5mg a week. I can’t imagine even thinking of eating at a higher dose. I know Steve and others are concerned about long term side effects and I agree it’s still a big unknown but when I see people on any of the glp1s taking 10mg+ doses it’s crazy to me.

Everything could/can have a side effect but if you keep it at a very reasonable dose you are mitigating the risk.

One of my fav people on tiktok Dawson Weiss (formerly DTREN) I chat with he’s at 6mg a week and he looks insane.
 
I stopped at 1.5mg a week. I can’t imagine even thinking of eating at a higher dose. I know Steve and others are concerned about long term side effects and I agree it’s still a big unknown but when I see people on any of the glp1s taking 10mg+ doses it’s crazy to me.

Everything could/can have a side effect but if you keep it at a very reasonable dose you are mitigating the risk.

One of my fav people on tiktok Dawson Weiss (formerly DTREN) I chat with he’s at 6mg a week and he looks insane.
i recently saw his update haha but didnt know he was on 6mg holy shit, how do people manage that?

im still on 1.5mg and its been working great so i have no reason to up it, wont be prepping until next year so hopefully by then we learn some more haha
 
i recently saw his update haha but didnt know he was on 6mg holy shit, how do people manage that?

im still on 1.5mg and its been working great so i have no reason to up it, wont be prepping until next year so hopefully by then we learn some more haha

its social media

they exagerate, lie and say whatever to get clicks. bostin lloyd used to say that people needed to use 4-5grams of gear a week, he did it for clicks and it worked. the strategy of gaining followers by saying or doing outrageous things is the way many market themselves.
 
yeah a lot of people on semaglutide dont train or take anabolics etc, they just eat less shit food so basically they waste away, crazyness
The ozempic sides, semaglutide sides are mainly due to bad eating habits.
You can see in @Likwid log, proper use of psyllium and proper dosing helps a lot.

Without training, high protein and digestive aids, semaglutide is hard to use.
 
The ozempic sides, semaglutide sides are mainly due to bad eating habits.
You can see in @Likwid log, proper use of psyllium and proper dosing helps a lot.

Without training, high protein and digestive aids, semaglutide is hard to use.
Yea so many people think you can keep eating shit food while on ozempic.

You can and you will lose weight because you feel full or nauseous. Then you have to keep jacking up doses you continue with weight loss. It’s a vicious cycle.

Small doses with a good diet and training it’s a wonder drug and can be used safely. Retatrutide is the king of them all though.
 
Yea so many people think you can keep eating shit food while on ozempic.

You can and you will lose weight because you feel full or nauseous. Then you have to keep jacking up doses you continue with weight loss. It’s a vicious cycle.

Small doses with a good diet and training it’s a wonder drug and can be used safely. Retatrutide is the king of them all though.
I had DEXA scans in 3 different time periods.

Near the end of a bulk cycle, after being injured for a year but losing a bunch of weight from Ozempic and NOT eating enough protein, and then again after losing more weight but doing a recomp cycle.

Lean Mass (Fat mass) in Pounds
End of Bulk (pre Ozempic): 183 (64)
After being Injured (on Ozempic, not enough protein): 152 (53)
After Recomp cycle (on Ozempic, not enough protein): 169 (23)
After Recomp cycle (lower Ozempic, enough protein): TBD!

Will be getting another DEXA after this recomp.

Just goes to show.... Gotta feed the body
 
I had DEXA scans in 3 different time periods.

Near the end of a bulk cycle, after being injured for a year but losing a bunch of weight from Ozempic and NOT eating enough protein, and then again after losing more weight but doing a recomp cycle.

Lean Mass (Fat mass) in Pounds
End of Bulk (pre Ozempic): 183 (64)
After being Injured (on Ozempic, not enough protein): 152 (53)
After Recomp cycle (on Ozempic, not enough protein): 169 (23)
After Recomp cycle (lower Ozempic, enough protein): TBD!

Will be getting another DEXA after this recomp.

Just goes to show.... Gotta feed the body
for those just reading the convo, @Likwid has a log up here https://www.evolutionary.org/forums/threads/likwid-2024-2025-diet-and-cycle-log.102254/, he's had an amazing body transformation , true champion at heart, real EVO family brother ;)
 
They are going in stages of efficacy and improvements, etc...

I sat in on a multitude of conferences at the A4M this year and some other biohacking conventions and have also had some pretty in depth discussions with some of the best naturopathic doctors in the world and have gotten a ton of insight on GLP-1 Agonists and in depth analysis and understanding of the main three, ozempic, mounjaro and now retatrutide...

in short, mounjaro (tirzepatide) has the added GIP receptor which makes it stronger than ozempic (semaglutide) but then retatrutide goes one step fruther and you get the following three...

  • GIP (Gastric Inhibitory Polypeptide) receptor
  • GLP-1 (Glucagon-Like Peptide-1) receptor
  • GCG (Glucagon) receptor

Heres a recent 48 week trial that was done on people with obesity, or overweight with weight-related conditions—except type 2 diabetes.


Dosage24-Week Results48-Week Results
1 mg7.2%8.7%
4 mg12.9%16.3%
8 mg17.3%23.9%
12 mg17.5%24.2%
Placebo1.6% 2.1%

Retatutride vs Tirzepatide vs Semaglutide: A Comparison

MedicationWeight LossDurationType of Receptor AgonistFDA-approval for Weight Loss
Retatrutide24.2%48 weeksTripleTrials Ongoing
Semaglutide20%68 weeksSingleYes, under Wegovy
Tirzepatide26.6%84 weeksDualYes, under Zepbound




Here are some ACTUAL study data showing the downside that has been seen with it so far

In clinical trials, retatrutide has shown promising results for weight loss, but like any medication, it comes with potential side effects and considerations. Phase II trial results did include data on adverse events:

  • A significant percentage of participants (73% to 94%) reported adverse events while taking retatrutide, particularly in the higher 8-mg and 12-mg groups.
  • The most commonly experienced side effects were gastrointestinal issues, including nausea, diarrhea, vomiting, and constipation.
  • Digestive side effects mainly occurred during the dose escalation phase and were mostly mild to moderate in severity—lower starting doses seemed to lessen this severity.
  • There were slight increases in certain digestive enzyme levels, such as amylase and lipase. But there was only one reported serious case of pancreatitis.
  • Participants taking higher doses of retatrutide experienced an increase in heart rate during the first 24 weeks, after which it decreased.
  • No serious cases of low blood sugar or significant complications like thyroid cancer were reported among participants.
  • Some individuals (7% of those on retatrutide compared to 1% on placebo) experienced skin sensitivity, but these cases were not serious.


There is a firm belief it will eventually get through trials and be on bigger than the others and with the amount of money in this market now, i would venture to guess that to be true.. i will be doing a TON more in terms of discussion and study on it along with all GLP-1's and have been developing a significant amount of knowledge base on them because there are some pretty insane comments and opinions out there amongst media, social media etc. that are just insanely off base and non factual so it can be difficult to sift through the bull shit but im on it!
 
They are going in stages of efficacy and improvements, etc...

I sat in on a multitude of conferences at the A4M this year and some other biohacking conventions and have also had some pretty in depth discussions with some of the best naturopathic doctors in the world and have gotten a ton of insight on GLP-1 Agonists and in depth analysis and understanding of the main three, ozempic, mounjaro and now retatrutide...

in short, mounjaro (tirzepatide) has the added GIP receptor which makes it stronger than ozempic (semaglutide) but then retatrutide goes one step fruther and you get the following three...

  • GIP (Gastric Inhibitory Polypeptide) receptor
  • GLP-1 (Glucagon-Like Peptide-1) receptor
  • GCG (Glucagon) receptor

Heres a recent 48 week trial that was done on people with obesity, or overweight with weight-related conditions—except type 2 diabetes.



Dosage24-Week Results48-Week Results
1 mg7.2%8.7%
4 mg12.9%16.3%
8 mg17.3%23.9%
12 mg17.5%24.2%
Placebo1.6%2.1%

Retatutride vs Tirzepatide vs Semaglutide: A Comparison


MedicationWeight LossDurationType of Receptor AgonistFDA-approval for Weight Loss
Retatrutide24.2%48 weeksTripleTrials Ongoing
Semaglutide20%68 weeksSingleYes, under Wegovy
Tirzepatide26.6%84 weeksDualYes, under Zepbound



Here are some ACTUAL study data showing the downside that has been seen with it so far

In clinical trials, retatrutide has shown promising results for weight loss, but like any medication, it comes with potential side effects and considerations. Phase II trial results did include data on adverse events:

  • A significant percentage of participants (73% to 94%) reported adverse events while taking retatrutide, particularly in the higher 8-mg and 12-mg groups.
  • The most commonly experienced side effects were gastrointestinal issues, including nausea, diarrhea, vomiting, and constipation.
  • Digestive side effects mainly occurred during the dose escalation phase and were mostly mild to moderate in severity—lower starting doses seemed to lessen this severity.
  • There were slight increases in certain digestive enzyme levels, such as amylase and lipase. But there was only one reported serious case of pancreatitis.
  • Participants taking higher doses of retatrutide experienced an increase in heart rate during the first 24 weeks, after which it decreased.
  • No serious cases of low blood sugar or significant complications like thyroid cancer were reported among participants.
  • Some individuals (7% of those on retatrutide compared to 1% on placebo) experienced skin sensitivity, but these cases were not serious.


There is a firm belief it will eventually get through trials and be on bigger than the others and with the amount of money in this market now, i would venture to guess that to be true.. i will be doing a TON more in terms of discussion and study on it along with all GLP-1's and have been developing a significant amount of knowledge base on them because there are some pretty insane comments and opinions out there amongst media, social media etc. that are just insanely off base and non factual so it can be difficult to sift through the bull shit but im on it!
@dylangemelli I found retatrutide easier to handle for most of my clients. :D no digestive issues like with semgaltudie. Limited now ith Tirzepatide but for sure Retatrutide is one of the best.
The most sides I saw was from semaglutide, even with micro dosing it has sides, @Pigsy just did micro dosing log with semgalutide, it's up here
https://www.evolutionary.org/forums/threads/semaglutide-ozempic-log.102197/
 
They are going in stages of efficacy and improvements, etc...

I sat in on a multitude of conferences at the A4M this year and some other biohacking conventions and have also had some pretty in depth discussions with some of the best naturopathic doctors in the world and have gotten a ton of insight on GLP-1 Agonists and in depth analysis and understanding of the main three, ozempic, mounjaro and now retatrutide...

in short, mounjaro (tirzepatide) has the added GIP receptor which makes it stronger than ozempic (semaglutide) but then retatrutide goes one step fruther and you get the following three...

  • GIP (Gastric Inhibitory Polypeptide) receptor
  • GLP-1 (Glucagon-Like Peptide-1) receptor
  • GCG (Glucagon) receptor

Heres a recent 48 week trial that was done on people with obesity, or overweight with weight-related conditions—except type 2 diabetes.



Dosage24-Week Results48-Week Results
1 mg7.2%8.7%
4 mg12.9%16.3%
8 mg17.3%23.9%
12 mg17.5%24.2%
Placebo1.6%2.1%

Retatutride vs Tirzepatide vs Semaglutide: A Comparison


MedicationWeight LossDurationType of Receptor AgonistFDA-approval for Weight Loss
Retatrutide24.2%48 weeksTripleTrials Ongoing
Semaglutide20%68 weeksSingleYes, under Wegovy
Tirzepatide26.6%84 weeksDualYes, under Zepbound



Here are some ACTUAL study data showing the downside that has been seen with it so far

In clinical trials, retatrutide has shown promising results for weight loss, but like any medication, it comes with potential side effects and considerations. Phase II trial results did include data on adverse events:

  • A significant percentage of participants (73% to 94%) reported adverse events while taking retatrutide, particularly in the higher 8-mg and 12-mg groups.
  • The most commonly experienced side effects were gastrointestinal issues, including nausea, diarrhea, vomiting, and constipation.
  • Digestive side effects mainly occurred during the dose escalation phase and were mostly mild to moderate in severity—lower starting doses seemed to lessen this severity.
  • There were slight increases in certain digestive enzyme levels, such as amylase and lipase. But there was only one reported serious case of pancreatitis.
  • Participants taking higher doses of retatrutide experienced an increase in heart rate during the first 24 weeks, after which it decreased.
  • No serious cases of low blood sugar or significant complications like thyroid cancer were reported among participants.
  • Some individuals (7% of those on retatrutide compared to 1% on placebo) experienced skin sensitivity, but these cases were not serious.


There is a firm belief it will eventually get through trials and be on bigger than the others and with the amount of money in this market now, i would venture to guess that to be true.. i will be doing a TON more in terms of discussion and study on it along with all GLP-1's and have been developing a significant amount of knowledge base on them because there are some pretty insane comments and opinions out there amongst media, social media etc. that are just insanely off base and non factual so it can be difficult to sift through the bull shit but im on it!
Thanks Dylan as always for the info and appreciate your responses to my questions as well!

Im again gonna be in the 1.5mg/week range with the umbrella labs retatrutide and so far so good!

Will also be running my bloods soon just to see if anything looks out of the ordinary but I feel great so not expecting anything.
 
@dylangemelli I found retatrutide easier to handle for most of my clients. :D no digestive issues like with semgaltudie. Limited now ith Tirzepatide but for sure Retatrutide is one of the best.
The most sides I saw was from semaglutide, even with micro dosing it has sides, @Pigsy just did micro dosing log with semgalutide, it's up here
https://www.evolutionary.org/forums/threads/semaglutide-ozempic-log.102197/
Yes, so far i have found it quite tolerable for everyone i have monitored on it as well! Good info bro
 
Thanks Dylan as always for the info and appreciate your responses to my questions as well!

Im again gonna be in the 1.5mg/week range with the umbrella labs retatrutide and so far so good!

Will also be running my bloods soon just to see if anything looks out of the ordinary but I feel great so not expecting anything.
awesome bro, let me know how everything goes!
 
Yes, so far i have found it quite tolerable for everyone i have monitored on it as well! Good info bro
@dylangemelli I think retatrutide will be the new "ozempic" hyped glp-1 but one that actually has little sides.
 
just less of an appetite supression at low dose like ozempic, but more overall benefits without the sides for sure
I think the side effects are the real issue with semaglutide. When compared to retatrutide its night and day but I bet thats not for all, depends on the individual to a degree as well. @Oracle911
 
I think the side effects are the real issue with semaglutide. When compared to retatrutide its night and day but I bet thats not for all, depends on the individual to a degree as well. @Oracle911
ive been on 1mg for like 4 months and then 1.5mg for another 2 on top and i feel fine in all ways shapes and forms, also body hasnt gotten used to it which is great, granted im doing it more for health purposes but i like not having to up it constantly.
 
@dylangemelli I think retatrutide will be the new "ozempic" hyped glp-1 but one that actually has little sides.
Its just going in stages... i would look at it in comparison to say

viagara
cialis
levitra

as they came out, they just got better and had added benefits, less sides etc... here they are just making improvements each time while actually enhancing the efficacy and results
 
Its just going in stages... i would look at it in comparison to say

viagara
cialis
levitra

as they came out, they just got better and had added benefits, less sides etc... here they are just making improvements each time while actually enhancing the efficacy and results
@dylangemelli I actually found tadalafil (cialis) much better than viagra or the later released levitra, interesting enough. Since we are on the topic, your thoughts on levitra? you test it vs cialis?
 
@dylangemelli I actually found tadalafil (cialis) much better than viagra or the later released levitra, interesting enough. Since we are on the topic, your thoughts on levitra? you test it vs cialis?
People tend to respond differently.. one of the draws to cialis was the longer half life to it, which for some is certainly ideal but for others, it can be quite problematic.. .levitra does take about an hour to really kick in so you need to keep that in mind but it is very strong, essentially a stronger version of viagara... so scaling, viagara would technically be the "weakest" yet still strong, then levitra and then cialis however cialis is NOT for everyone based on upon the long half life and chances of issues with too long of an erection etc... ive tried them all in the past, and to be honest, just personally, i always liked viagara myself... but the best was the old superman stack when you got all three LOL
 
People tend to respond differently.. one of the draws to cialis was the longer half life to it, which for some is certainly ideal but for others, it can be quite problematic.. .levitra does take about an hour to really kick in so you need to keep that in mind but it is very strong, essentially a stronger version of viagara... so scaling, viagara would technically be the "weakest" yet still strong, then levitra and then cialis however cialis is NOT for everyone based on upon the long half life and chances of issues with too long of an erection etc... ive tried them all in the past, and to be honest, just personally, i always liked viagara myself... but the best was the old superman stack when you got all three LOL
i find viagra gives me headaches like a mofo bro but cialis is fine no problem, levitra didnt use it much just 1-2 times i think didnt feel jack shit
we should find a member who stacked all 3 @dylangemelli
we have @RoidRage69 with dual stack but I did that too, havent added levitra for a triple stack haha
I had viagra and Cialis on my anniversary night. I can vouch it's way more effective to stack them.
 
i find viagra gives me headaches like a mofo bro but cialis is fine no problem, levitra didnt use it much just 1-2 times i think didnt feel jack shit
we should find a member who stacked all 3 @dylangemelli
we have @RoidRage69 with dual stack but I did that too, havent added levitra for a triple stack haha
@Sydneycitysupplements cock boom (viagra and Cialis) half a tablet works great for me. To be honest first time hearing of a 3rd supp.
 
can check my log too if you want, have been using it throughout my growth phase, been on 2mg up from 1.5mg up from 1mg, have been running it for about 6 months non stock now, all that has happened is visceral fat has gotten less and less over time and i stay leaner, am on 2mg now and at my highest calories growing leaner than ive everbeen,

TD 4300
NTD 3000
feel free to check it out, very much recommend reta though :) very multipurpose, think lantus with the shuttling without the sides
 
can check my log too if you want, have been using it throughout my growth phase, been on 2mg up from 1.5mg up from 1mg, have been running it for about 6 months non stock now, all that has happened is visceral fat has gotten less and less over time and i stay leaner, am on 2mg now and at my highest calories growing leaner than ive everbeen,

TD 4300
NTD 3000
feel free to check it out, very much recommend reta though :) very multipurpose, think lantus with the shuttling without the sides
For new readers just starting this thread, @Oracle911 has a log with ratatrutide in the stack
https://www.evolutionary.org/forums...eq-hgh-retatrutide-slupp332-cycle-log.103518/
 
Well it worked! Clocked in at 248.8 pounds today and still only using 2mg/week!

Gonna drop it and kick start May 1st the test/primo/dhb/var cycle wish me luck!
You should add a touchdown pic of the retatrutide brand you are using @awm1981
I like umbrella labs retatrutide, it's quality.
 
Hey guys,

Retatrutide anecdote here a couple of weeks following the Aus National Championships:

Ret. was absolutely game changing for me when it came to energy and satiety during contest prep. Alongside some other compounds (I'll list below), I didn't experience any fatigue until around two weeks out. VERY lean.

Rebound hunger signaling following the ret. clearing out (around 3 weeks from last administration), has been absolutely brutal. Never experienced anything like it. Currently in a reverse diet, so the food is highER than contest prep but still quite low. It's made an effective reverse diet super hard.

Compounds used during prep that align with the ret.

- 5 Amino 1MQ
- SLU PP 332
- Methylene Blue
- Kaizen (L-carnitine, NAD, Choline blend)
- Clen
 
Hey guys,

Retatrutide anecdote here a couple of weeks following the Aus National Championships:

Ret. was absolutely game changing for me when it came to energy and satiety during contest prep. Alongside some other compounds (I'll list below), I didn't experience any fatigue until around two weeks out. VERY lean.

Rebound hunger signaling following the ret. clearing out (around 3 weeks from last administration), has been absolutely brutal. Never experienced anything like it. Currently in a reverse diet, so the food is highER than contest prep but still quite low. It's made an effective reverse diet super hard.

Compounds used during prep that align with the ret.

- 5 Amino 1MQ
- SLU PP 332
- Methylene Blue
- Kaizen (L-carnitine, NAD, Choline blend)
- Clen
@R. AP I think the "withdrawal" we are talking about with retatrutide is related to being post show as well. I think if you were just doing a cycle and eating clean no issues, but with the full show prep it would make you VERY hungry as you come off. This is a very unique case.
 
Hey guys,

Retatrutide anecdote here a couple of weeks following the Aus National Championships:

Ret. was absolutely game changing for me when it came to energy and satiety during contest prep. Alongside some other compounds (I'll list below), I didn't experience any fatigue until around two weeks out. VERY lean.

Rebound hunger signaling following the ret. clearing out (around 3 weeks from last administration), has been absolutely brutal. Never experienced anything like it. Currently in a reverse diet, so the food is highER than contest prep but still quite low. It's made an effective reverse diet super hard.

Compounds used during prep that align with the ret.

- 5 Amino 1MQ
- SLU PP 332
- Methylene Blue
- Kaizen (L-carnitine, NAD, Choline blend)
- Clen
@R. AP thanks for this update man. unfortunately there are rebound effects on these GLP's .. i'm on reta too and its a miracle peptide, i've witnessed people i know have crazy results but coming off is brutal i would imagine
 
Hey guys,

Retatrutide anecdote here a couple of weeks following the Aus National Championships:

Ret. was absolutely game changing for me when it came to energy and satiety during contest prep. Alongside some other compounds (I'll list below), I didn't experience any fatigue until around two weeks out. VERY lean.

Rebound hunger signaling following the ret. clearing out (around 3 weeks from last administration), has been absolutely brutal. Never experienced anything like it. Currently in a reverse diet, so the food is highER than contest prep but still quite low. It's made an effective reverse diet super hard.

Compounds used during prep that align with the ret.

- 5 Amino 1MQ
- SLU PP 332
- Methylene Blue
- Kaizen (L-carnitine, NAD, Choline blend)
- Clen
@R. AP bro you running some modern shit for sure. me i just like going old school with tren and mast
 
Hey guys,

Retatrutide anecdote here a couple of weeks following the Aus National Championships:

Ret. was absolutely game changing for me when it came to energy and satiety during contest prep. Alongside some other compounds (I'll list below), I didn't experience any fatigue until around two weeks out. VERY lean.

Rebound hunger signaling following the ret. clearing out (around 3 weeks from last administration), has been absolutely brutal. Never experienced anything like it. Currently in a reverse diet, so the food is highER than contest prep but still quite low. It's made an effective reverse diet super hard.

Compounds used during prep that align with the ret.

- 5 Amino 1MQ
- SLU PP 332
- Methylene Blue
- Kaizen (L-carnitine, NAD, Choline blend)
- Clen
@R. AP Bros, you're gonna see a lot of people using these glps

They got a lot of benefits.
 
Hey guys,

Retatrutide anecdote here a couple of weeks following the Aus National Championships:

Ret. was absolutely game changing for me when it came to energy and satiety during contest prep. Alongside some other compounds (I'll list below), I didn't experience any fatigue until around two weeks out. VERY lean.

Rebound hunger signaling following the ret. clearing out (around 3 weeks from last administration), has been absolutely brutal. Never experienced anything like it. Currently in a reverse diet, so the food is highER than contest prep but still quite low. It's made an effective reverse diet super hard.

Compounds used during prep that align with the ret.

- 5 Amino 1MQ
- SLU PP 332
- Methylene Blue
- Kaizen (L-carnitine, NAD, Choline blend)
- Clen
@R. AP wow nice update. sorry to hear about appetite rebound. it might be something you have to keep taking at low dosages year round
 
Hey guys,

Retatrutide anecdote here a couple of weeks following the Aus National Championships:

Ret. was absolutely game changing for me when it came to energy and satiety during contest prep. Alongside some other compounds (I'll list below), I didn't experience any fatigue until around two weeks out. VERY lean.

Rebound hunger signaling following the ret. clearing out (around 3 weeks from last administration), has been absolutely brutal. Never experienced anything like it. Currently in a reverse diet, so the food is highER than contest prep but still quite low. It's made an effective reverse diet super hard.

Compounds used during prep that align with the ret.

- 5 Amino 1MQ
- SLU PP 332
- Methylene Blue
- Kaizen (L-carnitine, NAD, Choline blend)
- Clen
@R. AP You get rebound from a lot of different compounds.. it completely make sense.
 
Hey guys,

Retatrutide anecdote here a couple of weeks following the Aus National Championships:

Ret. was absolutely game changing for me when it came to energy and satiety during contest prep. Alongside some other compounds (I'll list below), I didn't experience any fatigue until around two weeks out. VERY lean.

Rebound hunger signaling following the ret. clearing out (around 3 weeks from last administration), has been absolutely brutal. Never experienced anything like it. Currently in a reverse diet, so the food is highER than contest prep but still quite low. It's made an effective reverse diet super hard.

Compounds used during prep that align with the ret.

- 5 Amino 1MQ
- SLU PP 332
- Methylene Blue
- Kaizen (L-carnitine, NAD, Choline blend)
- Clen
@R. AP Thanks for updating us. You're taking a lot of unique things. It's good to hear that. It's working out for you. And some of the trial and error that you're going through,
 
Hey guys,

Retatrutide anecdote here a couple of weeks following the Aus National Championships:

Ret. was absolutely game changing for me when it came to energy and satiety during contest prep. Alongside some other compounds (I'll list below), I didn't experience any fatigue until around two weeks out. VERY lean.

Rebound hunger signaling following the ret. clearing out (around 3 weeks from last administration), has been absolutely brutal. Never experienced anything like it. Currently in a reverse diet, so the food is highER than contest prep but still quite low. It's made an effective reverse diet super hard.

Compounds used during prep that align with the ret.

- 5 Amino 1MQ
- SLU PP 332
- Methylene Blue
- Kaizen (L-carnitine, NAD, Choline blend)
- Clen
That's a good peptide stack
 
Hey guys,

Retatrutide anecdote here a couple of weeks following the Aus National Championships:

Ret. was absolutely game changing for me when it came to energy and satiety during contest prep. Alongside some other compounds (I'll list below), I didn't experience any fatigue until around two weeks out. VERY lean.

Rebound hunger signaling following the ret. clearing out (around 3 weeks from last administration), has been absolutely brutal. Never experienced anything like it. Currently in a reverse diet, so the food is highER than contest prep but still quite low. It's made an effective reverse diet super hard.

Compounds used during prep that align with the ret.

- 5 Amino 1MQ
- SLU PP 332
- Methylene Blue
- Kaizen (L-carnitine, NAD, Choline blend)
- Clen
@R. AP man that sounds brutal. I’d say it has to do with it being a show prep also
 
Hey guys,

Retatrutide anecdote here a couple of weeks following the Aus National Championships:

Ret. was absolutely game changing for me when it came to energy and satiety during contest prep. Alongside some other compounds (I'll list below), I didn't experience any fatigue until around two weeks out. VERY lean.

Rebound hunger signaling following the ret. clearing out (around 3 weeks from last administration), has been absolutely brutal. Never experienced anything like it. Currently in a reverse diet, so the food is highER than contest prep but still quite low. It's made an effective reverse diet super hard.

Compounds used during prep that align with the ret.

- 5 Amino 1MQ
- SLU PP 332
- Methylene Blue
- Kaizen (L-carnitine, NAD, Choline blend)
- Clen
@R. AP the coming off part is a bit rough for many guys bro....stay on track you'll get through it........
 
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